Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.42 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2067900 | 0.78 | DHODH (0.49) | MAPTDHODHKDM4EKMT2ALMNA | |
| SCHEMBL29501236 | 0.73 | BTK (0.50) | MAPTDHODHSQORNPC1RAB9A | |
| SCHEMBL13422264 | 0.70 | DHODH (0.53) | MAPTDHODHMEN1KMT2ASQOR | |
| SCHEMBL29488279 | 0.69 | ESR1 (0.58) | MAPTDHODHKDM4EMEN1KMT2A | |
| SCHEMBL9601498 | 0.69 | ESR1 (0.58) | MAPTDHODHKDM4EMEN1KMT2A | |
| SCHEMBL1083765 | 0.68 | MAPT (1.00) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL8818671 | 0.68 | TGFBR1 (0.49) | MAPTDHODHLMNAALDH1A1GAA | |
| SCHEMBL4056518 | 0.67 | DHODH (0.54) | MAPTDHODHMEN1KMT2ASQOR | |
| SCHEMBL21445639 | 0.65 | MAPK14 (0.38) | MAPTDHODHKDM4EMEN1KMT2A | |
| SCHEMBL21445433 | 0.65 | MAPK14 (0.38) | MAPTDHODHKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |