Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 17/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20680164 | 0.90 | ALPL (0.48) | ALPLPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL20680161 | 0.88 | KMT2A (0.51) | ALPLSHMT2MEN1KMT2A | |
| SCHEMBL20680421 | 0.83 | ALPL (0.60) | ALPLSHMT2MEN1POLBKMT2A | |
| SCHEMBL9954777 | 0.80 | PIK3CD (0.56) | ALPLSHMT2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL19211730 | 0.80 | SHMT2 (0.51) | ALPLSHMT2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL9953447 | 0.79 | SHMT2 (0.49) | ALPLSHMT2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL806771 | 0.79 | SHMT2 (0.55) | ALPLSHMT2MEN1KMT2A | |
| SCHEMBL9953524 | 0.78 | SHMT2 (0.54) | ALPLSHMT2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL20680714 | 0.77 | PIK3CD (0.67) | ALPLPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL16996889 | 0.77 | PIK3C3 (0.59) | SHMT2MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019020657-A1 | PYRIDINE-3-SULFONAMIDE COMPOUNDS AS PI3-KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-31 | — | — | WO | disclosed |
| WO-2019020657-A1 | PYRIDINE-3-SULFONAMIDE COMPOUNDS AS PI3-KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-31 | — | — | WO | disclosed |