Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953524 | 0.88 | SHMT2 (0.54) | SHMT2SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL9954777 | 0.88 | PIK3CD (0.56) | SHMT2ALPLNPC1MEN1KMT2A | |
| SCHEMBL806765 | 0.86 | LMNA (0.53) | SHMT2SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL9953447 | 0.82 | SHMT2 (0.49) | SHMT2ALPLNPC1MEN1KMT2A | |
| SCHEMBL806782 | 0.80 | SMN1; SMN2 (0.54) | SHMT2SMN1; SMN2LMNAALDH1A1ALPL | |
| SCHEMBL19211730 | 0.80 | SHMT2 (0.51) | SHMT2ALDH1A1ALPLNPC1MEN1 | |
| SCHEMBL9953641 | 0.79 | SHMT2 (0.44) | SHMT2SMN1; SMN2ALDH1A1ALPLNPC1 | |
| SCHEMBL20680705 | 0.79 | ALPL (0.48) | SHMT2ALPLMEN1KMT2A | |
| SCHEMBL15211892 | 0.78 | ALPL (0.72) | SMN1; SMN2LMNAALDH1A1ALPL | |
| SCHEMBL16926620 | 0.77 | PIK3C3 (0.61) | SHMT2LMNAALPLKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |