Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18088401 | 0.79 | P2RX7 (0.75) | P2RX7HDAC6CXCR3HDAC4HDAC8 | |
| SCHEMBL21241378 | 0.77 | CXCR3 (0.39) | P2RX7HDAC6CXCR3HDAC4HDAC8 | |
| SCHEMBL21241381 | 0.76 | P2RX7 (0.52) | P2RX7HDAC6CXCR3HDAC4HDAC8 | |
| SCHEMBL16327151 | 0.64 | PYCR1 (0.50) | CXCR3PYCR1CNR2 | |
| SCHEMBL21241565 | 0.64 | PYCR1 (0.39) | P2RX7HDAC6CXCR3HDAC4HDAC8 | |
| SCHEMBL22951079 | 0.63 | P2RX7 (0.68) | P2RX7HDAC6CXCR3HDAC4HDAC8 | |
| SCHEMBL16312619 | 0.63 | PYCR1 (0.65) | PYCR1ALDH1A1 | |
| SCHEMBL7297585 | 0.61 | PYCR1 (0.59) | PYCR1CNR2ALDH1A1 | |
| SCHEMBL20535891 | 0.60 | HDAC6 (0.73) | P2RX7HDAC6CXCR3HDAC4HDAC8 | |
| SCHEMBL20535265 | 0.60 | HDAC6 (1.00) | P2RX7HDAC6HDAC4HDAC8HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10188756-B2 | Imaging histone deacetylases with a radiotracer using positron emission tomography | THE GENERAL HOSPITAL CORPORATION (US) | 2019-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10188756-B2 | Imaging histone deacetylases with a radiotracer using positron emission tomography | HDAC1, HDAC11, HDAC3 | P2RX7 4700/4885HDAC6 13/4885CXCR3 3531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.