Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | ARG1 | P05089 | 1/20 | 0.44 |
| ▸ | ARG2 | P78540 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20683452 | 0.85 | ARG1 (0.60) | CHRM2SCN8AARG1ARG2GAA | |
| SCHEMBL895647 | 0.84 | ARG1 (0.60) | CHRM2ARG1ARG2KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL895379 | 0.83 | ARG1 (0.58) | CHRM2ARG1ARG2KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL895165 | 0.82 | ARG1 (0.57) | CHRM2ARG1ARG2KDM4EMEN1 | |
| SCHEMBL20677461 | 0.80 | MMP2 (0.32) | CHRM2ARG1ARG2CA12CA1 | |
| SCHEMBL20683349 | 0.78 | MTNR1A (0.48) | CHRM2SCN8AHDAC1 | |
| SCHEMBL20683367 | 0.78 | PPARA (0.41) | ARG1ARG2MEN1KMT2AATM | |
| SCHEMBL15363355 | 0.78 | CHRM2 (0.54) | CHRM2SCN8AGAAKDM4EMEN1 | |
| SCHEMBL2938432 | 0.73 | CHRM2 (0.78) | CHRM2SCN8AGAAKDM4EMEN1 | |
| SCHEMBL20683360 | 0.73 | ARG1 (0.68) | SCN8AARG1ARG2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |