Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | ARG1 | P05089 | 5/20 | 0.51 |
| ▸ | ARG2 | P78540 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30169814 | 0.85 | ARG1 (0.73) | ACHEARG1ARG2 | |
| SCHEMBL895625 | 0.85 | ARG1 (0.73) | ACHEARG1ARG2 | |
| Hydrochloric Acid SCHEMBL894489 | 0.84 | ARG1 (0.71) | ACHEARG1ARG2 | |
| SCHEMBL20683444 | 0.84 | ARG1 (0.49) | ARG1ARG2HDAC8HDAC6SLC6A4 | |
| SCHEMBL20683435 | 0.82 | ARG1 (0.72) | ACHEARG1ARG2 | |
| SCHEMBL20683475 | 0.81 | ARG1 (0.56) | ACHEARG1ARG2MEN1KMT2A | |
| SCHEMBL20683450 | 0.78 | ARG1 (0.57) | ACHEARG1ARG2MEN1KMT2A | |
| SCHEMBL20683441 | 0.77 | ARG1 (0.74) | ARG1ARG2MEN1KMT2A | |
| SCHEMBL20683485 | 0.77 | ARG1 (0.71) | ARG1ARG2MEN1KMT2A | |
| SCHEMBL10207115 | 0.77 | ACHE (0.51) | ACHEMEN1KMT2ATSHRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |