Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 4/20 | 0.34 |
| ▸ | IL17A | Q16552 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13841149 | 0.78 | ALDH1A1 (0.48) | TSHRTDP1ALDH1A1ATMKMT2A | |
| SCHEMBL12894331 | 0.78 | ADRA2A (0.48) | TSHRMAPK1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL23516584 | 0.77 | KMT2A (0.39) | TDP1ALDH1A1KMT2ANISCH | |
| SCHEMBL20893237 | 0.77 | MEN1 (0.43) | ALDH1A1HPGDKMT2ARORC | |
| SCHEMBL15014119 | 0.77 | APP (0.41) | MAPK1ALDH1A1TAAR1KMT2A | |
| SCHEMBL6872347 | 0.77 | ESR1 (0.44) | TDP1ALDH1A1CYP3A4TAAR1HPGD | |
| SCHEMBL21122428 | 0.76 | RORC (0.38) | TSHRMAPK1TDP1ALDH1A1ATM | |
| SCHEMBL19654951 | 0.76 | ATM (0.36) | TSHRMAPK1TDP1ALDH1A1ATM | |
| SCHEMBL11498639 | 0.76 | TAAR1 (0.38) | ALDH1A1ATMTAAR1KMT2ALPL | |
| SCHEMBL1554057 | 0.76 | HTR2A (0.48) | TDP1ALDH1A1L3MBTL1TAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233848-B1 | BENZENESULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RES & DEV (FR) | 2019-01-30 | — | — | EP | disclosed |