Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18923218 | 0.77 | GABRA1 (0.37) | LMNACYP3A4TDP1ALDH1A1KDM4E | |
| SCHEMBL20172629 | 0.77 | FAAH (0.42) | LMNAMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29304969 | 0.71 | MEN1 (0.37) | LMNAALDH1A1KDM4ECA12CA2 | |
| SCHEMBL6662276 | 0.71 | ALDH1A1 (0.36) | LMNACYP3A4CXCR2MAPTNPC1 | |
| SCHEMBL23510092 | 0.70 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL20272959 | 0.69 | ALDH1A1 (0.43) | LMNACYP3A4CXCR2MAPTNPC1 | |
| SCHEMBL134637 | 0.68 | EP300 (0.52) | LMNACYP3A4CXCR2MAPTNPC1 | |
| SCHEMBL31276399 | 0.68 | EP300 (0.52) | LMNACYP3A4CXCR2MAPTNPC1 | |
| SCHEMBL18157920 | 0.68 | CXCR2 (0.49) | LMNACYP3A4CXCR2MAPTNPC1 | |
| SCHEMBL27966636 | 0.68 | BTK (0.40) | LMNACXCR2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046927-B1 | POLYCYCLIC PHENYLPYRIDINE IRIDIUM COMPLEXES AND DERIVATIVES THEREOF FOR OLEDS | MERCK PATENT GMBH (DE) | 2019-01-30 | — | — | EP | disclosed |