Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21155495 | 0.84 | GAA (0.35) | GAANFKB1NFKB2RELARXFP1 | |
| SCHEMBL29032266 | 0.69 | NFKB1 (0.39) | GAANFKB1NFKB2RELARXFP1 | |
| SCHEMBL22272897 | 0.67 | KDM4E (0.36) | GAACA1CA12CA14CA2 | |
| SCHEMBL29415863 | 0.66 | CYP17A1 (0.37) | GAARXFP1NAMPTCYP17A1ATR | |
| SCHEMBL13055402 | 0.63 | CYP17A1 (0.59) | GAANAMPTCYP17A1CA1CA12 | |
| SCHEMBL23683074 | 0.63 | EPHX2 (0.36) | GAANFKB1NFKB2RELACYP17A1 | |
| SCHEMBL19970150 | 0.63 | NFKB1 (0.36) | GAANFKB1NFKB2RELACYP17A1 | |
| SCHEMBL14110260 | 0.62 | EPHX2 (0.42) | GAANFKB1NFKB2RELANAMPT | |
| SCHEMBL16166476 | 0.61 | GAA (0.39) | GAANFKB1NFKB2RELARXFP1 | |
| SCHEMBL27657273 | 0.61 | NFKB1 (0.38) | GAANFKB1NFKB2RELARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |