Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | CASP1 | P29466 | 3/20 | 0.36 |
| ▸ | CASP7 | P55210 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA7 | P43166 | 3/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | TLR4 | O00206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2267862 | 0.82 | CA12 (0.41) | KDM4EALDH1A1HSD17B10POLBCA12 | |
| SCHEMBL8767264 | 0.68 | HSD17B10 (0.33) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL23215807 | 0.68 | KDM4E (0.37) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL20689331 | 0.67 | GAA (0.35) | GAACA12CA1CA2CA7 | |
| SCHEMBL25753203 | 0.67 | TLR4 (0.38) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL12228858 | 0.65 | ALDH1A1 (0.38) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL21776592 | 0.63 | LMNA (0.43) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL28515648 | 0.63 | ALDH1A1 (0.33) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL18856494 | 0.63 | CHRNB2 (0.31) | ALDH1A1 | |
| SCHEMBL1538340 | 0.62 | PTPN1 (0.30) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154474-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-07-30 | — | — | WO | disclosed |