Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22340256 | 0.87 | ALDH1A1 (0.39) | ALDH1A1LMNAALBMAPK1IMPDH2 | |
| SCHEMBL20692032 | 0.83 | ALDH1A1 (0.38) | ALDH1A1LMNAALBMAPK1IMPDH2 | |
| SCHEMBL20782639 | 0.82 | ALDH1A1 (0.40) | ALDH1A1LMNAALBMAPK1POLB | |
| SCHEMBL20692199 | 0.81 | ALDH1A1 (0.31) | ALDH1A1LMNAALBMAPK1 | |
| SCHEMBL20692218 | 0.81 | ALDH1A1 (0.31) | ALDH1A1LMNAALBMAPK1 | |
| SCHEMBL24060672 | 0.81 | ALDH1A1 (0.39) | ALDH1A1LMNAALBMAPK1 | |
| SCHEMBL22340326 | 0.79 | POLB (0.42) | POLB | |
| SCHEMBL22340218 | 0.74 | IMPDH2 (0.44) | IMPDH2IMPDH1POLBTAS1R3TAS1R1 | |
| SCHEMBL24680745 | 0.72 | SLC29A1 (0.32) | — | |
| SCHEMBL22340207 | 0.72 | POLB (0.41) | IMPDH2IMPDH1POLBTAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658565-B1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2022-11-09 | — | — | EP | disclosed |
| WO-2019023459-A1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-31 | — | — | WO | disclosed |