SCHEMBL20692026

COP(O)(=S)OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]c4nccn4c32)[C@H](OP(O)(=S)OC[C@H]2C[C@@H](n3cnc4c(O)ncnc43)[C@@H]2C)C1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	STING1	Q86WV6	1/20	0.32

▸	FHIT	P49789	2/20	0.31

▸	RNASEL	Q05823	5/20	0.31

▸	DTYMK	P23919	2/20	0.31

▸	IMPDH2	P12268	1/20	0.31

▸	IMPDH1	P20839	1/20	0.31

▸	ENPP1	P22413	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20691956	0.84	RNASEL (0.40)	RNASELDTYMKENPP1
SCHEMBL24680655	0.71	NT5E (0.40)	FHITRNASELDTYMK
SCHEMBL22349197	0.70	DTYMK (0.42)	DTYMKENPP1
SCHEMBL20691322	0.68	POLB (0.41)	DTYMKENPP1
SCHEMBL20692011	0.67	ALDH1A1 (0.37)	IMPDH2IMPDH1
SCHEMBL24060484	0.67	RNASEL (0.45)	RNASELDTYMK
SCHEMBL24258651	0.66	RNASEL (0.45)	RNASEL
SCHEMBL20691405	0.65	DTYMK (0.41)	RNASELDTYMKENPP1
SCHEMBL20691965	0.65	RNASEL (0.45)	FHITRNASELENPP1
SCHEMBL22340326	0.65	POLB (0.42)	FHITDTYMKENPP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3658565-B1	CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS	BRISTOL MYERS SQUIBB CO (US)	2022-11-09	—	—	EP	disclosed
WO-2019023459-A1	CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS	BRISTOL-MYERS SQUIBB COMPANY (US)	2019-01-31	—	—	WO	disclosed