Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | G6PD | P11413 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | CHAT | P28329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2998732 | 1.00 | NPC1 (1.00) | NPC1RAB9AMAOBNFE2L2FBP1 | |
| SCHEMBL13164321 | 1.00 | NPC1 (1.00) | NPC1RAB9AMAOBNFE2L2FBP1 | |
| SCHEMBL12349220 | 0.83 | RAB9A (0.70) | NPC1RAB9AALDH1A1MAPK1LMNA | |
| SCHEMBL2995976 | 0.83 | RAB9A (0.70) | NPC1RAB9AALDH1A1MAPK1LMNA | |
| Hydrochloric Acid SCHEMBL3390220 | 0.82 | RAB9A (0.68) | NPC1RAB9AALDH1A1MAPK1LMNA | |
| SCHEMBL7972788 | 0.79 | NPC1 (0.64) | NPC1RAB9AALDH1A1MAPK1LMNA | |
| SCHEMBL12411092 | 0.75 | NPC1 (0.60) | NPC1RAB9AMAOBNFE2L2ALDH1A1 | |
| SCHEMBL7972705 | 0.73 | NPC1 (0.57) | NPC1RAB9ANFE2L2ALDH1A1MAPK1 | |
| SCHEMBL12349218 | 0.73 | ALDH1A1 (0.73) | NPC1RAB9ANFE2L2FBP1ALDH1A1 | |
| SCHEMBL264277 | 0.73 | ALDH1A1 (0.73) | NPC1RAB9ANFE2L2FBP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166170-A1 | SYNTHESIS OF AVRAINVILLAMIDE, STEPHACIDIN B, AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | US | disclosed |
| US-7902196-B2 | Synthesis of avrainvillamide, strephacidin B, and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-03-08 | — | — | US | disclosed |
| US-20090143581-A1 | SYNTHESIS OF AVRAINVILLAMIDE, STREPHACIDIN B, AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-06-04 | — | — | US | disclosed |
| US-3988159-A | Light-sensitive material containing nitrone for forming heat-fixed images | AMERICAN CAN COMPANY (US) | 1976-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166170-A1 | SYNTHESIS OF AVRAINVILLAMIDE, STEPHACIDIN B, AND ANALOGUES THEREOF | MDN1, VASP, ATRIP | NPC1 3731/4885RAB9A 1761/4885MAOB 2163/4885 |
| US-20090143581-A1 | SYNTHESIS OF AVRAINVILLAMIDE, STREPHACIDIN B, AND ANALOGUES THEREOF | MDN1, BIRC3, STAMBP | NPC1 3752/4885RAB9A 2439/4885MAOB 2402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.