SCHEMBL2069360

SCHEMBL2069360

COC(=O)c1ccccc1N1CCCC(C(=O)NCc2ccc(-c3ccc(Cl)cc3)cc2)C1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.54
TP53 P04637 4/20 0.54
LMNA P02545 2/20 0.53
ALK Q9UM73 3/20 0.49
IGF1R P08069 1/20 0.49
GPBAR1 Q8TDU6 4/20 0.49
POLB P06746 1/20 0.49
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2069037 0.85 PPARA (0.51) MAPTTP53LMNAALKGPBAR1
SCHEMBL2069118 0.83 BCL9 (0.55) MAPTTP53LMNAALKIGF1R
SCHEMBL2070654 0.80 ALDH1A1 (0.51) MAPTLMNAKDM4EALDH1A1
SCHEMBL2070104 0.77 NOTUM (0.53) MAPTTP53POLBKDM4EALDH1A1
SCHEMBL2071685 0.77 DRD2 (0.52)
SCHEMBL2069992 0.77 PPARA (0.56) MAPTTP53LMNAGPBAR1POLB
SCHEMBL2069318 0.77 PPARA (0.56) MAPTTP53LMNAGPBAR1POLB
SCHEMBL2072276 0.77 PPARA (0.56) MAPTTP53LMNAGPBAR1POLB
SCHEMBL12844724 0.76 PPARA (0.63) MAPTTP53GPBAR1
SCHEMBL2070653 0.75 SLC6A3 (0.41) MAPTLMNAPOLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
EP-1780210-A1 NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-05-02 EP disclosed
EP-1780210-A1 NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative PPARA, PPARG, PPARD MAPT 4544/4885TP53 2840/4885LMNA 1906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.