Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
| ▸ | NRP1 | O14786 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | RAMP3 | O60896 | 3/20 | 0.39 |
| ▸ | CALCR | P30988 | 3/20 | 0.39 |
| ▸ | GRB2 | P62993 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30404662 | 0.93 | OPRM1 (0.48) | OPRM1OPRK1EPHA2NRP1 | |
| SCHEMBL22803172 | 0.89 | OPRM1 (0.43) | OPRM1OPRK1EPHA2NRP1 | |
| SCHEMBL24668333 | 0.88 | GRB2 (0.38) | OPRM1OPRK1NRP1GRB2 | |
| SCHEMBL29571998 | 0.86 | OPRM1 (0.48) | OPRM1OPRK1EPHA2NRP1RAMP3 | |
| SCHEMBL30416412 | 0.85 | GRB2 (0.47) | OPRM1OPRK1EPHA2NRP1RAMP3 | |
| SCHEMBL29802094 | 0.84 | OPRM1 (0.45) | OPRM1OPRK1EPHA2NRP1RAMP3 | |
| SCHEMBL22872708 | 0.84 | NRP1 (0.54) | OPRM1OPRK1EPHA2NRP1GRB2 | |
| SCHEMBL20694547 | 0.84 | NRP1 (0.46) | OPRM1OPRK1EPHA2NRP1RAMP3 | |
| SCHEMBL29572497 | 0.84 | OPRM1 (0.55) | OPRM1OPRK1CXCR4 | |
| SCHEMBL22803169 | 0.83 | NRP1 (0.45) | OPRM1OPRK1EPHA2NRP1RAMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021102052-A1 | DIRECTED CONJUGATION TECHNOLOGIES | KLEO PHARMACEUTICALS, INC. (US) | 2021-05-27 | — | — | WO | disclosed |
| WO-2021003050-A2 | CD38-BINDING AGENTS AND USES THEREOF | KLEO PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |
| WO-2020132588-A1 | COMBINATION THERAPY OF ARMS AND NATURAL KILLER CELLS | KLEO PHARMACEUTICALS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2019023501-A1 | UNIVERSAL ABT COMPOUNDS AND USES THEREOF | KLEO PHARMACEUTICALS, INC. (US) | 2019-01-31 | — | — | WO | disclosed |