SCHEMBL20696243

SCHEMBL20696243

COCC(=O)N1Cc2[nH]nc(C(=O)N3CCC(c4ccccc4C(F)(F)F)CC3)c2C1

nearest known ligand 0.60

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RBP4 P02753 20/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20952916 0.93 RBP4 (0.64) RBP4
SCHEMBL17505260 0.93 RBP4 (0.63) RBP4
SCHEMBL29598307 0.93 RBP4 (0.63) RBP4
SCHEMBL20589480 0.92 RBP4 (0.57) RBP4
SCHEMBL29597931 0.92 RBP4 (0.57) RBP4
SCHEMBL17505280 0.91 RBP4 (0.71) RBP4
SCHEMBL29597989 0.91 RBP4 (0.71) RBP4
SCHEMBL20696200 0.89 RBP4 (0.60) RBP4
SCHEMBL17505282 0.89 RBP4 (0.72) RBP4
SCHEMBL29598015 0.89 RBP4 (0.72) RBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250241902-A1 METHODS, COMPOSITIONS AND SYSTEMS FOR EVALUATION OF VISUAL FUNCTION BELITE BIO INC (US) 2025-07-31 US disclosed
US-12364693-B2 Methods of treating metabolic diseases with fused bicyclic pyrazoles BELITE BIO, INC (US) 2025-07-22 US disclosed
CN-120129485-A Methods, compositions, and systems for assessing visual function 英属开曼群岛商倍亮生物有限公司 2025-06-10 CN disclosed
EP-4507566-A1 METHODS, COMPOSITIONS AND SYSTEMS FOR EVALUATION OF VISUAL FUNCTION Belite Bio, Inc (US) 2025-02-19 EP disclosed
CN-119454705-A Formulations and methods of use of RBP4 inhibitors 倍亮生物有限责任公司 2025-02-18 CN disclosed
US-20250041227-A1 TABLET FORMULATIONS OF RBP4 INHIBITORS AND METHODS OF USE BELITE BIO INC (US) 2025-02-06 US disclosed
EP-4436577-A1 TABLET FORMULATIONS OF RBP4 INHIBITORS AND METHODS OF USE Belite Bio, Inc (US) 2024-10-02 EP disclosed
CN-118574615-A Tablet formulations of RBP4 inhibitors and methods of use 倍亮生物有限公司 2024-08-30 CN disclosed
US-20240248099-A1 BIOMARKERS FOR AGE-RELATED MACULAR DEGENERATION BELITE BIO, LLC 2024-07-25 US disclosed
US-11951100-B2 Formulations of RBP4 inhibitors and methods of use BELITE BIO, LLC (US) 2024-04-09 US disclosed
EP-3996714-A1 FORMULATIONS OF RBP4 INHIBITORS AND METHODS OF USE Belite Bio, LLC (US) 2022-05-18 EP disclosed
CN-114364382-A Formulations and methods of use of RBP4 inhibitors 倍亮生物有限责任公司 2022-04-15 CN disclosed
US-20210363155-A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-11-25 US disclosed
US-11028098-B2 4-phenylpiperidines, their preparation and use THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-06-08 US disclosed
WO-2021007172-A1 FORMULATIONS OF RBP4 INHIBITORS AND METHODS OF USE BELITE BIO, LLC (US) 2021-01-14 WO disclosed
US-20200197390-A1 METHODS OF TREATING METABOLIC DISEASES WITH FUSED BICYCLIC PYRAZOLES BELITE BIO, INC (KY) 2020-06-25 US disclosed
US-20200197390-A1 METHODS OF TREATING METABOLIC DISEASES WITH FUSED BICYCLIC PYRAZOLES BELITE BIO, INC (KY) 2020-06-25 US disclosed
WO-2020028723-A1 RBP4 ANTAGONISTS FOR TREATMENT AND PREVENTION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND GOUT THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2020-02-06 WO disclosed
US-10273243-B2 4-phenylpiperidines, their preparation and use THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-04-30 US disclosed
US-20190031681-A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-01-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10273243-B2 4-phenylpiperidines, their preparation and use HTR3C, HRH4, CYP4F3 RBP4 2619/4885
US-20250241902-A1 METHODS, COMPOSITIONS AND SYSTEMS FOR EVALUATION OF VISUAL FUNCTION PDE6C, SERPINA6, PDE6H RBP4 11/4885
US-12364693-B2 Methods of treating metabolic diseases with fused bicyclic pyrazoles RBP4, RBP1, FABP4 RBP4 1/4885
US-20200197390-A1 METHODS OF TREATING METABOLIC DISEASES WITH FUSED BICYCLIC PYRAZOLES RBP4, RBP1, FABP4 RBP4 1/4885
US-20240248099-A1 BIOMARKERS FOR AGE-RELATED MACULAR DEGENERATION AGER, RBP4, RBP1 RBP4 2/4885
US-20210363155-A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE HTR3C, HRH4, CYP4F3 RBP4 2807/4885
US-20250041227-A1 TABLET FORMULATIONS OF RBP4 INHIBITORS AND METHODS OF USE RBP4, RBP1, RBM3 RBP4 1/4885
US-11028098-B2 4-phenylpiperidines, their preparation and use HTR3C, HRH4, CYP4F3 RBP4 2660/4885
US-20190031681-A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE HTR3C, HRH4, CYP4F3 RBP4 2660/4885
US-11951100-B2 Formulations of RBP4 inhibitors and methods of use RBP4, RBP1, RBM3 RBP4 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.