Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | TET3 | O43151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.47 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20708184 | 0.89 | ADAMTS5 (0.47) | RAB9ATET3KMT2AFBXL19CXXC5 | |
| SCHEMBL17871381 | 0.86 | RAB9A (0.54) | RAB9ACHRM2CHRM4ADRB1CHRM1 | |
| SCHEMBL21583811 | 0.84 | AKR1C3 (0.61) | RAB9ATET3KMT2AFBXL19CXXC5 | |
| SCHEMBL17884901 | 0.83 | RAB9A (0.72) | RAB9AKMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL17884496 | 0.81 | RAB9A (0.54) | RAB9ACHRM2CHRM4ADRB1CHRM1 | |
| SCHEMBL20708171 | 0.81 | LMNA (0.49) | ALDH1A1HTTSMN1; SMN2KDM4EJAK3 | |
| SCHEMBL20708157 | 0.80 | JAK3 (0.52) | RAB9AALDH1A1SMN1; SMN2JAK3ADAMTS5 | |
| SCHEMBL5414205 | 0.79 | CHRM2 (0.52) | RAB9ACHRM2CHRM4ADRB1CHRM1 | |
| SCHEMBL17640832 | 0.79 | CYP17A1 (0.47) | RAB9AKMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL11068888 | 0.78 | ADRB1 (0.70) | CHRM2CHRM4ADRB1CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3575294-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Les Laboratoires Servier (FR) | 2019-12-04 | — | — | EP | disclosed |
| EP-3237406-B1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2019-02-06 | — | — | EP | disclosed |