Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 3/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734348 | 0.89 | GABRA1 (0.50) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL3088973 | 0.77 | GABRA1 (0.43) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL21736785 | 0.75 | GABRA1 (0.52) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL9336892 | 0.75 | GABRA1 (0.52) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL15371487 | 0.75 | GABRA1 (0.44) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL12446949 | 0.75 | GABRA1 (0.41) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL6546378 | 0.75 | L3MBTL1 (0.46) | L3MBTL1DAOHTR2A | |
| SCHEMBL24448361 | 0.73 | LMNA (0.30) | LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL18243183 | 0.73 | GABRA1 (0.54) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL8346810 | 0.72 | GABRA1 (0.46) | GABRA1GABRB2L3MBTL1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4001269-A1 | BENZOISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | Amgen Inc. (US) | 2022-05-25 | — | — | EP | disclosed |
| WO-2019025467-A1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NodThera Limited (GB) | 2019-02-07 | — | — | WO | disclosed |