Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 3/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31553839 | 0.78 | RAF1 (0.40) | RAF1ACVRL1ACVR1GRM5MEN1 | |
| SCHEMBL29520297 | 0.78 | CYP2C19 (0.44) | CYP2C19CYP2C9CYP1A2ALDH1A1KDM4E | |
| SCHEMBL3440728 | 0.78 | CYP2C19 (0.44) | CYP2C19CYP2C9CYP1A2ALDH1A1KDM4E | |
| SCHEMBL3440773 | 0.74 | MAOA (0.40) | CYP2C19 | |
| SCHEMBL31553854 | 0.69 | CYP11B2 (0.34) | RAF1GRM5ALDH1A1KDM4EMEN1 | |
| SCHEMBL8030862 | 0.67 | GRM5 (0.56) | GRM5ALDH1A1KDM4EKMT2A | |
| SCHEMBL31553816 | 0.65 | NR1H2 (0.39) | MAPT | |
| SCHEMBL5863676 | 0.65 | CDC7 (0.40) | KDM4E | |
| Hydrochloric Acid SCHEMBL11067822 | 0.65 | CYP2C19 (0.44) | CYP2C19CYP2C9GRM5CYP1A2ALDH1A1 | |
| SCHEMBL31553851 | 0.65 | CDC7 (0.40) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590128-B2 | 6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine dopamine D3 ligands | PFIZER, INC. (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190047997-A1 | 6,7,8,9-TETRAHYDRO-5H-PYRIDO[2,3-d]AZEPINE DOPAMINE D3 LIGANDS | PFIZER INC. (US) | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590128-B2 | 6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine dopamine D3 ligands | DRD3, DRD2, DRD4 | CYP2C19 122/4885RAF1 2443/4885CYP2C9 346/4885 |
| US-20190047997-A1 | 6,7,8,9-TETRAHYDRO-5H-PYRIDO[2,3-d]AZEPINE DOPAMINE D3 LIGANDS | DRD3, DRD2, DRD4 | CYP2C19 122/4885RAF1 2443/4885CYP2C9 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.