Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25138002 | 0.92 | FTO (0.52) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL22197942 | 0.92 | FTO (0.53) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL23599906 | 0.90 | FTO (0.51) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL24723090 | 0.90 | FTO (0.51) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL23599828 | 0.89 | FTO (0.50) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL995937 | 0.88 | FTO (0.49) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL27087723 | 0.88 | FTO (0.51) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL29924010 | 0.88 | FTO (0.51) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL19431891 | 0.87 | FTO (0.49) | FTOMEN1MAPTHPGDCYP2C19 | |
| SCHEMBL17956704 | 0.85 | FTO (0.60) | FTOMEN1MAPTHPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3665161-B1 | NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2023-09-27 | — | — | EP | disclosed |
| US-11236059-B2 | Targeted cytotoxic ratjadone derivatives and conjugates thereof | HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH (DE) | 2022-02-01 | — | — | US | disclosed |
| US-20200239426-A1 | TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH (DE) | 2020-07-30 | — | — | US | disclosed |
| EP-3665161-A1 | NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019030284-A1 | NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2019-02-14 | — | — | WO | disclosed |
| US-9447413-B2 | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs | Regulus Therapeutics Inc. (US) | 2016-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236059-B2 | Targeted cytotoxic ratjadone derivatives and conjugates thereof | PICALM, CD47, RABGGTB | FTO 4792/4885MEN1 4813/4885MAPT 824/4885 |
| US-20200239426-A1 | TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | PICALM, CD47, RABGGTB | FTO 4792/4885MEN1 4813/4885MAPT 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.