Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 8/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23599906 | 0.90 | FTO (0.51) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL20723482 | 0.88 | FTO (0.56) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL31343967 | 0.88 | GSTP1 (0.58) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL22197942 | 0.88 | FTO (0.53) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL25138002 | 0.88 | FTO (0.52) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL24723090 | 0.86 | FTO (0.51) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL23599828 | 0.85 | FTO (0.50) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL30112575 | 0.85 | NT5E (0.41) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL24942496 | 0.85 | NT5E (0.41) | FTOTTRKCNH2MEN1MAPT | |
| SCHEMBL29924010 | 0.84 | FTO (0.51) | FTOTTRKCNH2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028424-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2021-06-08 | — | — | US | disclosed |
| US-10604745-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | PROMEGA CORPORATION (US) | 2020-03-31 | — | — | US | disclosed |
| US-20190218592-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION | 2019-07-18 | — | — | US | disclosed |
| US-10240184-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2019-03-26 | — | — | US | disclosed |
| US-20190085305-A1 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2019-03-21 | — | — | US | disclosed |
| EP-3179252-B1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORP (US) | 2018-11-14 | — | — | EP | disclosed |
| US-10101332-B2 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION (US) | 2018-10-16 | — | — | US | disclosed |
| EP-3179252-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | Promega Corporation (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2395078-B1 | Covalent tethering of functional groups to proteins | PROMEGA CORP (US) | 2017-05-10 | — | — | EP | disclosed |
| US-20170097356-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2017-04-06 | — | — | US | disclosed |
| US-20080026407-A1 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION | 2008-01-31 | — | — | US | disclosed |
| US-7238842-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| EP-1782071-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006093529-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060024808-A1 | Covalent tethering of functional groups to proteins and substrates therefor | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2006-02-02 | — | — | US | disclosed |
| US-20050272114-A1 | Substrates for covalent tethering to proteins | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2005-12-08 | — | — | US | disclosed |
| EP-1594962-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040214258-A1 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION | 2004-10-28 | — | — | US | disclosed |
| WO-2004072232-A9 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORP (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004072232-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272114-A1 | Substrates for covalent tethering to proteins | DDHD2, ABHD14B, AHCYL1 | FTO 2893/4885TTR 4306/4885KCNH2 4721/4885 |
| US-20170097356-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | WASF2, NOTUM, YIPF5 | FTO 2876/4885TTR 4528/4885KCNH2 4806/4885 |
| US-20190085305-A1 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE | HDHD5, DDT, DDAH1 | FTO 345/4885TTR 3360/4885KCNH2 4724/4885 |
| US-20190218592-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | GGT1, HDHD5, DNPH1 | FTO 2948/4885TTR 4212/4885KCNH2 4657/4885 |
| US-10604745-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | HDHD5, DDT, DDAH1 | FTO 345/4885TTR 3360/4885KCNH2 4724/4885 |
| US-11028424-B2 | Covalent tethering of functional groups to proteins | GGT1, HDHD5, DNPH1 | FTO 2948/4885TTR 4212/4885KCNH2 4657/4885 |
| US-20080026407-A1 | Covalent tethering of functional groups to proteins | GGT1, HDHD5, DNPH1 | FTO 2948/4885TTR 4212/4885KCNH2 4657/4885 |
| US-10101332-B2 | Covalent tethering of functional groups to proteins and substrates therefor | WASF2, NOTUM, YIPF5 | FTO 2876/4885TTR 4528/4885KCNH2 4806/4885 |
| US-20060024808-A1 | Covalent tethering of functional groups to proteins and substrates therefor | WASF2, NOTUM, YIPF5 | FTO 2876/4885TTR 4528/4885KCNH2 4806/4885 |
| US-10240184-B2 | Covalent tethering of functional groups to proteins | GGT1, HDHD5, DNPH1 | FTO 2948/4885TTR 4212/4885KCNH2 4657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.