Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CPA3 | P15088 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL28422380 | 0.93 | REN (0.39) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL28971378 | 0.92 | ANPEP (0.43) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL21925068 | 0.91 | REN (0.41) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL29048350 | 0.91 | ANPEP (0.46) | RENANPEPRNPEPDNPEPALPI | |
| Phenylalanine SCHEMBL6139176 | 0.91 | ANPEP (0.46) | RENANPEPRNPEPDNPEPALPI | |
| Phenylalanine SCHEMBL28711271 | 0.89 | REN (0.38) | RENANPEPRNPEPDNPEPOPRK1 | |
| Dl-Phenylalanine SCHEMBL28971371 | 0.89 | ANPEP (0.45) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL28854621 | 0.88 | OPRK1 (0.42) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL29067183 | 0.88 | GHSR (0.39) | RENANPEPRNPEPDNPEPALPI | |
| Tyrosine SCHEMBL28368606 | 0.88 | SLC7A5 (0.44) | RENANPEPRNPEPDNPEPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833185-B2 | Anti-neurodegenerative therapeutic, method of manufacture, and use | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2023-12-05 | — | — | US | disclosed |
| EP-3664831-B1 | ANTI-NEURODEGENERATIVE THERAPEUTIC AND USE | UNIV KENTUCKY RES FOUND (US) | 2023-06-14 | — | — | EP | disclosed |
| US-20200282007-A1 | ANTI-NEURODEGENERATIVE THERAPEUTIC, METHOD OF MANUFACTURE, AND USE | UNIV KENTUCKY RES FOUND (US) | 2020-09-10 | — | — | US | disclosed |
| EP-3664831-A1 | ANTI-NEURODEGENERATIVE THERAPEUTIC, METHOD OF MANUFACTURE, AND USE | University Of Kentucky Research Foundation (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019033099-A1 | ANTI-NEURODEGENERATIVE THERAPEUTIC, METHOD OF MANUFACTURE, AND USE | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-02-14 | — | — | WO | disclosed |