Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MIF | P14174 | 2/20 | 0.64 |
| ▸ | CD74 | P04233 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20725151 | 0.87 | MIF (0.76) | ALDH1A1SMN1; SMN2TP53MAPTKMT2A | |
| SCHEMBL20725152 | 0.81 | TP53 (0.55) | ALDH1A1TP53MAPTKMT2AMIF | |
| SCHEMBL18805691 | 0.79 | MIF (0.80) | ALDH1A1SMN1; SMN2TP53MAPTKMT2A | |
| SCHEMBL18805676 | 0.79 | KMT2A (0.76) | ALDH1A1SMN1; SMN2KMT2AMIFCD74 | |
| SCHEMBL16948357 | 0.79 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2TP53MAPTKMT2A | |
| SCHEMBL10874258 | 0.79 | MIF (1.00) | ALDH1A1SMN1; SMN2TP53KMT2AMIF | |
| SCHEMBL14822539 | 0.78 | MAPT (0.70) | ALDH1A1SMN1; SMN2TP53MAPTKMT2A | |
| SCHEMBL31667438 | 0.77 | MIF (0.71) | ALDH1A1SMN1; SMN2TP53MAPTKMT2A | |
| SCHEMBL10181870 | 0.76 | MAPT (0.75) | ALDH1A1SMN1; SMN2TP53MAPTKMT2A | |
| SCHEMBL2757851 | 0.76 | MIF (1.00) | ALDH1A1SMN1; SMN2KMT2AMIFCD74 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202343-B2 | MIF modulators | YALE UNIVERSITY (US) | 2019-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202343-B2 | MIF modulators | MIF, HMGB2, HMGB3 | ALDH1A1 584/4885SMN1; SMN2 3531/4885TP53 1948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.