Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071431 | 0.80 | KDM4E (0.55) | KDM4ESMN1; SMN2LMNAHSD17B10MAP2K4 | |
| SCHEMBL8638951 | 0.79 | GAA (0.50) | MAP2K4GAA | |
| SCHEMBL6599812 | 0.77 | KDM4E (0.70) | KDM4ERAB9ASMN1; SMN2LMNAMAPK10 | |
| SCHEMBL7374273 | 0.74 | GAA (0.54) | MAP2K4GAA | |
| SCHEMBL29084451 | 0.73 | GALR3 (0.68) | KDM4ERAB9ASMN1; SMN2LMNAMAPK10 | |
| SCHEMBL28566933 | 0.70 | POLB (0.65) | KDM4ERAB9ALMNAPOLBSLC6A2 | |
| SCHEMBL4791540 | 0.70 | KDM4E (0.59) | KDM4ESMN1; SMN2LMNAHSD17B10MAP2K4 | |
| SCHEMBL25205501 | 0.69 | KDM4E (0.58) | KDM4ERAB9ASMN1; SMN2LMNANPC1 | |
| SCHEMBL3810014 | 0.69 | KDM4E (0.58) | KDM4ERAB9ASMN1; SMN2LMNAMAPK10 | |
| SCHEMBL904609 | 0.69 | CYP1A2 (0.48) | KDM4ERAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897607-B2 | Cyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-01 | — | — | US | disclosed |