Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791540 | 0.90 | KDM4E (0.59) | KDM4ESTAT3HIF1ANR4A2GAA | |
| SCHEMBL25206400 | 0.83 | KDM4E (0.55) | KDM4ESTAT3HIF1ANR4A2FLT3 | |
| SCHEMBL8638951 | 0.82 | GAA (0.50) | GAAMAP2K4TTKEPHB3CHEK1 | |
| SCHEMBL2072624 | 0.80 | KDM4E (0.45) | KDM4EGAAMAP2K4LMNAHSD17B10 | |
| SCHEMBL7374273 | 0.77 | GAA (0.54) | GAAMAP2K4TTKEPHB3PBRM1 | |
| SCHEMBL2599805 | 0.77 | KDM4E (0.60) | KDM4ESTAT3HIF1ANR4A2FLT3 | |
| SCHEMBL14271999 | 0.75 | KDM4E (0.59) | KDM4ESTAT3HIF1ANR4A2GAA | |
| SCHEMBL7737920 | 0.75 | KDM4E (0.59) | KDM4ESTAT3HIF1AFLT3LRRK2 | |
| SCHEMBL2862825 | 0.75 | KDM4E (0.59) | KDM4ESTAT3HIF1ANR4A2MAP2K4 | |
| SCHEMBL28503864 | 0.74 | KDM4E (0.57) | KDM4ESTAT3HIF1ANR4A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522670-A1 | Heterocyclic CRF receptor antagonists | Takeda Pharmaceutical Company Limited (JP) | 2012-11-14 | — | — | EP | disclosed |
| US-7897607-B2 | Cyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-01 | — | — | US | disclosed |
| US-20070179165-A1 | Cyclic compounds | GYORKOS ALBERT C | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179165-A1 | Cyclic compounds | CRHR1, CRHR2, MC2R | KDM4E 3537/4885STAT3 1795/4885HIF1A 407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.