Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 3/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726366 | 0.88 | NEK1 (0.42) | PBKNEK1SLC6A4SLC6A3EGFR | |
| SCHEMBL20726451 | 0.81 | EGFR (0.39) | EGFRAURKAKDRAURKBMAOA | |
| SCHEMBL20726427 | 0.80 | BRD4 (0.42) | EGFRKDRMAOAMAOBCHEK1 | |
| SCHEMBL20726365 | 0.79 | PBK (0.41) | PBKNEK1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL20726354 | 0.77 | PRKAB2 (0.41) | PBKNEK1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL20726403 | 0.76 | CYP3A4 (0.38) | EGFRCHEK1 | |
| SCHEMBL20726478 | 0.75 | AURKA (0.39) | EGFRAURKAKDRAURKBCHEK1 | |
| SCHEMBL20726406 | 0.75 | EGFR (0.35) | PBKNEK1EGFRKDR | |
| SCHEMBL20726356 | 0.74 | PDE3B (0.35) | EGFRCHEK1 | |
| SCHEMBL20726419 | 0.72 | KDR (0.31) | KDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |