Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 2/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726451 | 0.81 | EGFR (0.39) | AURKAKDRAURKBEGFRCHEK1 | |
| SCHEMBL20726427 | 0.80 | BRD4 (0.42) | KDREGFRCHEK1 | |
| SCHEMBL20726476 | 0.76 | MMP2 (0.34) | AURKAKDRAURKBCHEK1GPR84 | |
| SCHEMBL20726420 | 0.75 | PBK (0.39) | AURKAKDRAURKBEGFRCHEK1 | |
| SCHEMBL20726364 | 0.74 | GPR84 (0.34) | AURKAKDRAURKBEGFRGPR84 | |
| SCHEMBL20726403 | 0.74 | CYP3A4 (0.38) | EGFRCHEK1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20726414 | 0.72 | MTNR1A (0.45) | KDRAURKBEGFRCHEK1PRKAB2 | |
| SCHEMBL20726356 | 0.72 | PDE3B (0.35) | EGFRCHEK1 | |
| SCHEMBL20726372 | 0.71 | HTR3A (0.51) | — | |
| SCHEMBL16824330 | 0.68 | MGAT2 (0.40) | AURKAKDRAURKBCHEK1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |