Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726451 | 0.88 | EGFR (0.39) | BRD4EGFRBACE1MAOAMAOB | |
| SCHEMBL20726403 | 0.81 | CYP3A4 (0.38) | BRD4EGFRCHEK1 | |
| SCHEMBL20726420 | 0.80 | PBK (0.39) | EGFRMAOAMAOBCHEK1KDR | |
| SCHEMBL20726478 | 0.80 | AURKA (0.39) | EGFRCHEK1KDR | |
| SCHEMBL20726356 | 0.79 | PDE3B (0.35) | BRD4EGFRBACE1CHEK1 | |
| SCHEMBL20726364 | 0.77 | GPR84 (0.34) | EGFRKDRPTGS2 | |
| SCHEMBL20726521 | 0.76 | NEK1 (0.31) | EGFR | |
| SCHEMBL20726381 | 0.71 | PGR (0.43) | BRD4EGFRKDRPDPK1 | |
| SCHEMBL20726382 | 0.70 | EGFR (0.48) | EGFRMAOACHEK1KDR | |
| SCHEMBL20726384 | 0.69 | PDE3B (0.50) | BRD4EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |