Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PON1 | P27169 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726427 | 0.88 | BRD4 (0.42) | EGFRCHEK1BRD4MAOAMAOB | |
| SCHEMBL20726403 | 0.82 | CYP3A4 (0.38) | EGFRCHEK1BRD4 | |
| SCHEMBL20726420 | 0.81 | PBK (0.39) | EGFRCHEK1MAOAMAOBKDR | |
| SCHEMBL20726478 | 0.81 | AURKA (0.39) | EGFRCHEK1KDRAURKBAURKA | |
| SCHEMBL20726356 | 0.80 | PDE3B (0.35) | EGFRPDE3BPDE3ACHEK1BRD4 | |
| SCHEMBL20726364 | 0.78 | GPR84 (0.34) | EGFRKDRAURKBAURKA | |
| SCHEMBL20726521 | 0.77 | NEK1 (0.31) | EGFR | |
| SCHEMBL20726384 | 0.71 | PDE3B (0.50) | EGFRPDE3BPDE3ABRD4KDR | |
| SCHEMBL20726441 | 0.71 | EGFR (0.40) | EGFRBRD4KDRPDPK1PIM1 | |
| SCHEMBL20726381 | 0.70 | PGR (0.43) | EGFRBRD4KDRPDPK1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |