Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726440 | 0.82 | PRKAB2 (0.38) | — | |
| SCHEMBL20726475 | 0.76 | KDM1A (0.33) | KDM1AMAOAKDR | |
| SCHEMBL20726424 | 0.73 | PRKAB2 (0.47) | BRD4 | |
| SCHEMBL20726403 | 0.73 | CYP3A4 (0.38) | BRD4EGFR | |
| SCHEMBL20726384 | 0.73 | PDE3B (0.50) | BRD4EGFRKDR | |
| SCHEMBL20726441 | 0.73 | EGFR (0.40) | BRD4EGFRBRD2KDR | |
| SCHEMBL20726366 | 0.72 | NEK1 (0.42) | BRD4EGFRMAOA | |
| SCHEMBL20726459 | 0.71 | BRD4 (0.38) | BRD4EGFRBRD2KDR | |
| SCHEMBL20726393 | 0.71 | EGFR (0.39) | BRD4EGFRBRD2KDR | |
| SCHEMBL20726416 | 0.71 | ALOX5 (0.41) | BRD4EGFRMAOAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |