Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20732472 | 0.87 | CYP3A4 (0.53) | CYP2A6CYP3A4ALDH1A1CYP1A2CYP19A1 | |
| SCHEMBL20732238 | 0.82 | CYP2A6 (0.47) | CYP2A6CYP3A4ALDH1A1CYP1A2CYP19A1 | |
| SCHEMBL21018823 | 0.82 | CYP2A6 (0.60) | CYP2A6CYP3A4ALDH1A1CYP1A2CYP19A1 | |
| SCHEMBL3785327 | 0.82 | NPC1 (0.68) | CYP2A6CYP3A4ALDH1A1CYP1A2CYP19A1 | |
| SCHEMBL30909387 | 0.81 | CYP2A6 (0.65) | CYP2A6CYP3A4ALDH1A1CYP1A2CYP19A1 | |
| SCHEMBL3230643 | 0.80 | CHRNB2 (0.53) | CYP2A6CYP2C19CHRNB2CHRNA4 | |
| SCHEMBL10109880 | 0.79 | TAAR1 (0.48) | ALDH1A1NPC1RAB9A | |
| SCHEMBL17524524 | 0.79 | TAAR1 (0.48) | ALDH1A1NPC1RAB9A | |
| SCHEMBL18323114 | 0.79 | ADRA2A (0.52) | CYP3A4ALDH1A1KMT2A | |
| SCHEMBL4400993 | 0.79 | ADRA2A (0.52) | CYP3A4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124534-B2 | Lincosamide antibiotics and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-09-21 | — | — | US | disclosed |
| US-20200339620-A1 | LINCOSAMIDE ANTIBIOTICS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-10-29 | — | — | US | disclosed |
| WO-2019032941-A1 | LINCOSAMIDE ANTIBIOTICS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-02-14 | — | — | WO | disclosed |
| WO-2019032936-A1 | LINCONSAMIDE ANTIBIOTICS AND USES THEREOF | PRESIDENT ADN FELLOWS OF HARVARD COLLEGE (US) | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124534-B2 | Lincosamide antibiotics and uses thereof | LNPEP, LCLAT1, NPEPPS | CYP2A6 157/4885CYP3A4 2000/4885ALDH1A1 1559/4885 |
| US-20200339620-A1 | LINCOSAMIDE ANTIBIOTICS AND USES THEREOF | LNPEP, LCLAT1, NPEPPS | CYP2A6 157/4885CYP3A4 2000/4885ALDH1A1 1559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.