Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2076283 | 0.76 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL30986042 | 0.76 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL7519732 | 0.75 | TSHR (0.37) | KDM4EALDH1A1HPGDLMNAPKM | |
| SCHEMBL26099756 | 0.69 | FBP1 (0.36) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL2074475 | 0.69 | MAP3K8 (0.40) | KDM4EALDH1A1HPGDHSD17B10MAPK1 | |
| SCHEMBL6017732 | 0.68 | KMT2A (0.39) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL186269 | 0.67 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL21048864 | 0.66 | ALDH1A1 (0.37) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL8377733 | 0.65 | TAS1R3 (0.34) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL31289614 | 0.64 | BTK (0.39) | KDM4EALDH1A1HPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |