Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ATM | Q13315 | 5/20 | 0.47 |
| ▸ | SLC14A1 | Q13336 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20722729 | 0.86 | PKM (0.40) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL20722528 | 0.81 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL23938072 | 0.72 | HSD17B10 (0.47) | SMN1; SMN2MAPTL3MBTL1MAPK1LIMK1 | |
| SCHEMBL20731142 | 0.72 | GAA (0.38) | SMN1; SMN2MAPTMAPK1HSD17B10GAA | |
| SCHEMBL27326539 | 0.71 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL23938071 | 0.69 | HSD17B10 (0.35) | MAPTMAPK1HSD17B10GAA | |
| SCHEMBL12562427 | 0.68 | LIMK1 (0.77) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL19769230 | 0.67 | KDM4E (1.00) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL20732017 | 0.67 | KDM4E (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL12562446 | 0.67 | SLC14A1 (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |