Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 12/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 12/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805213 | 1.00 | KDM4A (0.40) | KDM4AKDM4CKDM5AKDM7APHF8 | |
| SCHEMBL25657481 | 0.86 | UTS2R (0.33) | ALDH1A1FOLH1 | |
| SCHEMBL24157900 | 0.85 | ALDH1A1 (0.37) | KDM4AKDM4CKDM5AKDM7APHF8 | |
| SCHEMBL19381471 | 0.85 | ALDH1A1 (0.37) | KDM4AKDM4CKDM5AKDM7APHF8 | |
| SCHEMBL24642454 | 0.85 | KDM4A (0.40) | KDM4AKDM4CKDM5AKDM7APHF8 | |
| SCHEMBL25358066 | 0.84 | FOLH1 (0.38) | ALDH1A1FOLH1 | |
| SCHEMBL25358064 | 0.84 | FOLH1 (0.38) | ALDH1A1FOLH1 | |
| SCHEMBL8171418 | 0.83 | KDM4A (0.39) | KDM4AKDM4CKDM5AKDM7APHF8 | |
| SCHEMBL18373090 | 0.83 | ALDH1A1 (0.36) | KDM4AKDM4CKDM5AKDM7APHF8 | |
| SCHEMBL27383905 | 0.82 | BHMT (0.42) | KDM4AKDM4CKDM5APHF8FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019031614-A1 | ANTIBODY-DRUG CONJUGATES INCLUDING HEMIASTERLIN DERIVATIVE | 大日本住友製薬株式会社 | 2019-02-14 | — | — | WO | disclosed |