Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733369 | 0.82 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL6301715 | 0.78 | CRHR1 (0.82) | CRHR1 | |
| SCHEMBL6302106 | 0.74 | CRHR1 (0.87) | CRHR1 | |
| SCHEMBL6297565 | 0.73 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL6301726 | 0.71 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL8045813 | 0.69 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL6302111 | 0.68 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL5599657 | 0.68 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL5611393 | 0.66 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL21886139 | 0.64 | CRHR1 (0.68) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190048012-A1 | Triazolopyridines And Triazolopyrimidines That Lower Stress-Induced P-Tau | NANTNEURO, LLC | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048012-A1 | Triazolopyridines And Triazolopyrimidines That Lower Stress-Induced P-Tau | MAPT, CRH, CRHBP | CRHR1 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.