Benzimidazole

Benzimidazole

SCHEMBL2073386

O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.c1ccc2[nH]cnc2c1.c1ccc2[nH]cnc2c1

nearest known ligand 0.50

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
HTT P42858 2/20 0.50
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
CTNNB1 P35222 2/20 0.47
WNT3A P56704 2/20 0.47
NAMPT P43490 1/20 0.43
POLB P06746 3/20 0.41
MAPT P10636 1/20 0.41
NPC1 O15118 2/20 0.41
PARP1 P09874 2/20 0.41
PDPK1 O15530 1/20 0.41
CA12 O43570 1/20 0.41
ALOX15 P16050 1/20 0.41
CA9 Q16790 1/20 0.41
TNKS2 Q9H2K2 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
QPCT Q16769 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzimidazole SCHEMBL29397040 1.00 RAB9A (0.50) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL2020186 1.00 RAB9A (0.50) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL2075174 1.00 RAB9A (0.50) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL28329484 0.94 SMN1; SMN2 (0.46) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL16516335 0.87 SMN1; SMN2 (0.57) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL8901469 0.87 SMN1; SMN2 (0.57) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL4774682 0.85 KDM4E (0.56) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL16516333 0.84 KDM4E (0.54) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL4631509 0.84 SMN1; SMN2 (0.54) RAB9ASMN1; SMN2HTTKDM4EALDH1A1
Benzimidazole SCHEMBL158526 0.84 SMN1; SMN2 (0.54) RAB9ASMN1; SMN2HTTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7863294-B2 Heterocycle derivatives as histone deacetylase (HDAC) inhibitors INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2011-01-04 US disclosed
EP-1828171-A2 HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) 2007-09-05 EP disclosed
WO-2006061638-A2 HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) 2006-06-15 WO disclosed