Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.43 |
| ▸ | WNT3A | P56704 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzimidazole SCHEMBL2075174 | 0.94 | RAB9A (0.50) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL29397040 | 0.94 | RAB9A (0.50) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL2073386 | 0.94 | RAB9A (0.50) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL2020186 | 0.94 | RAB9A (0.50) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL28874195 | 0.87 | KDM4E (0.47) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL1533899 | 0.87 | KDM4E (0.47) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL11145219 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL8901469 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL16516335 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E | |
| Benzimidazole SCHEMBL4774682 | 0.80 | KDM4E (0.56) | SMN1; SMN2RAB9AALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325514-A | Trisubstituted -2- alkyl -1H- benzo [d] imdazole derivatives of 1,4,6- as dihydrooratic acid oxygenase inhibitor | 默克专利有限责任公司 | 2019-10-11 | — | — | CN | disclosed |