Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20734845 | 1.00 | CNR2 (0.39) | CNR2CNR1MEN1KMT2APARP10 | |
| SCHEMBL20734837 | 0.82 | L3MBTL1 (0.42) | CNR2CNR1MEN1KMT2APARP10 | |
| SCHEMBL20734964 | 0.81 | CNR1 (0.38) | CNR2CNR1MEN1KMT2APARP10 | |
| SCHEMBL20734943 | 0.81 | CNR1 (0.38) | CNR2CNR1MEN1KMT2APARP10 | |
| SCHEMBL20734917 | 0.79 | AKR1B1 (0.42) | MEN1KMT2APARP10ALDH1A1MAPT | |
| SCHEMBL20734918 | 0.79 | AKR1B1 (0.42) | MEN1KMT2APARP10ALDH1A1MAPT | |
| SCHEMBL24333190 | 0.75 | CYP2D6 (0.36) | CNR2CNR1MEN1KMT2APARP10 | |
| SCHEMBL21927113 | 0.73 | PRCP (0.31) | — | |
| SCHEMBL20734816 | 0.73 | MAOB (0.36) | MEN1KMT2AHPGD | |
| SCHEMBL20734815 | 0.73 | MAOB (0.36) | MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332440-B2 | 4-oxo-alkylated tetramic acid compound, and preparation method thereof | BEIJING JOEKAI BIOTECH. LLC (CN) | 2022-05-17 | — | — | US | disclosed |
| EP-3647306-B1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR | BEIJING JOEKAI BIOTECH LLC (CN) | 2022-04-06 | — | — | EP | disclosed |
| US-11130733-B2 | 4-OXO-alkylated tetramic acid compound, preparation method and use thereof | BEIJING JOEKAI BIOTECH. LLC (CN) | 2021-09-28 | — | — | US | disclosed |
| US-20200361868-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD AND USE THEREOF | BEIJING JOEKAI BIOTECH. LLC (CN) | 2020-11-19 | — | — | US | disclosed |
| US-20200181081-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, AND PREPARATION METHOD THEREOF | BEIJING JOEKAI BIOTECH. LLC (CN) | 2020-06-11 | — | — | US | disclosed |
| WO-2019029273-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
| WO-2019029274-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130733-B2 | 4-OXO-alkylated tetramic acid compound, preparation method and use thereof | HTT, PARK7, PSEN1 | CNR2 2277/4885CNR1 1876/4885MEN1 2261/4885 |
| US-11332440-B2 | 4-oxo-alkylated tetramic acid compound, and preparation method thereof | PSEN1, PSEN2, APP | CNR2 2672/4885CNR1 1902/4885MEN1 1113/4885 |
| US-20200181081-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, AND PREPARATION METHOD THEREOF | PSEN1, PSEN2, APP | CNR2 2672/4885CNR1 1902/4885MEN1 1113/4885 |
| US-20200361868-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD AND USE THEREOF | HTT, PARK7, PSEN1 | CNR2 2277/4885CNR1 1876/4885MEN1 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.