SCHEMBL20734852

SCHEMBL20734852

N#CC(NCl)c1ccco1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
POLB P06746 2/20 0.35
PKM P14618 1/20 0.35
PTPN1 P18031 1/20 0.35
PTPN7 P35236 1/20 0.35
BLM P54132 1/20 0.35
ESR2 Q92731 1/20 0.35
SGMS2 Q8NHU3 1/20 0.34
ALOX5 P09917 1/20 0.33
ALDH1A1 P00352 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
LMNA P02545 1/20 0.33
MEN1 O00255 3/20 0.32
KDM4E B2RXH2 2/20 0.32
MAPT P10636 2/20 0.32
HSD17B10 Q99714 2/20 0.32
AGTR1 P30556 1/20 0.32
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17429531 0.82 ALDH1A1 (0.37) KMT2AL3MBTL1POLBPKMPTPN1
SCHEMBL21938786 0.82 KMT2A (0.34) KMT2AL3MBTL1POLBPKMPTPN1
SCHEMBL21939143 0.82 KMT2A (0.34) KMT2AL3MBTL1POLBPKMPTPN1
SCHEMBL19173075 0.77 SGMS2 (0.36) KMT2AL3MBTL1POLBPKMPTPN1
SCHEMBL29160530 0.77 ALDH1A1 (0.37) KMT2AL3MBTL1SGMS2ALOX5ALDH1A1
SCHEMBL16055369 0.77 ALDH1A1 (0.47) KMT2AL3MBTL1POLBPKMPTPN1
SCHEMBL16055778 0.77 SGMS2 (0.45) KMT2AL3MBTL1SGMS2ALDH1A1SMN1; SMN2
SCHEMBL1492158 0.76 ALDH1A1 (0.39) KMT2AL3MBTL1POLBPKMPTPN1
SCHEMBL14761185 0.76 ALDH1A1 (0.39) KMT2AL3MBTL1POLBPKMPTPN1
SCHEMBL16055657 0.76 SGMS2 (0.47) KMT2AL3MBTL1POLBSGMS2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10550083-B2 Processes for the preparation of 4-alkoxy-3-hydroxypicolinic acids DOW AGROSCIENCES LLC (US) 2020-02-04 US disclosed
US-20190112271-A1 PROCESSES FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS CORTEVA AGRISCIENCE LLC 2019-04-18 US disclosed
US-20190047962-A1 PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-ACETOXYPICOLINIC ACIDS DOW AGROSCIENCES LLC (US) 2019-02-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190047962-A1 PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-ACETOXYPICOLINIC ACIDS HPD, HAAO, CA4 KMT2A 2171/4885L3MBTL1 4685/4885POLB 4116/4885
US-20190112271-A1 PROCESSES FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS HPD, HAAO, BLVRB KMT2A 2261/4885L3MBTL1 4491/4885POLB 1570/4885
US-10550083-B2 Processes for the preparation of 4-alkoxy-3-hydroxypicolinic acids HPD, HAAO, BLVRB KMT2A 2261/4885L3MBTL1 4491/4885POLB 1570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.