Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.39 |
| ▸ | TUBB | P07437 | 3/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28457354 | 0.82 | MEN1 (0.45) | MEN1KMT2ATSHRAPOBEC3AHTT | |
| SCHEMBL14543278 | 0.77 | KMT2A (0.50) | MEN1KMT2AMAPTACHETUBB4A | |
| SCHEMBL684136 | 0.77 | ACHE (0.52) | MAPTACHETUBB4ATUBBTUBA3C | |
| SCHEMBL20661178 | 0.76 | ALDH1A1 (0.45) | MEN1KMT2AALOX5TUBB4ATUBB | |
| SCHEMBL29177225 | 0.76 | KMT2A (0.47) | MEN1KMT2ATSHRMAPTKDM4E | |
| SCHEMBL9721680 | 0.75 | KMT2A (0.50) | MEN1KMT2ATSHRPOLBCYP3A4 | |
| SCHEMBL22442918 | 0.75 | TSHR (0.45) | MEN1KMT2ATSHRAPOBEC3AHTT | |
| SCHEMBL21101774 | 0.74 | CA12 (0.59) | MEN1KMT2ATSHRHTTMAPT | |
| SCHEMBL28823338 | 0.74 | KMT2A (0.48) | MEN1KMT2ATSHRMAPTKDM4E | |
| SCHEMBL736176 | 0.72 | TUBB4A (0.63) | MEN1KMT2AHTTMAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190048009-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048009-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | SYNCRIP, MYC, RPS27 | MEN1 804/4885KMT2A 3967/4885TSHR 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.