Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17872068 | 0.90 | ALDH1A1 (0.40) | ALDH1A1POLBSMN1; SMN2BTKEPHX2 | |
| SCHEMBL17872166 | 0.84 | ALDH1A1 (0.42) | ALDH1A1POLBSMN1; SMN2BTKEPHX2 | |
| Trifluoroacetic Acid SCHEMBL31220713 | 0.82 | PRKCB (0.40) | ALDH1A1POLBSMN1; SMN2BTKEPHX2 | |
| SCHEMBL17872119 | 0.82 | POLB (0.43) | ALDH1A1POLBSMN1; SMN2EPHX2LMNA | |
| SCHEMBL20741129 | 0.76 | PRKCB (0.46) | ALDH1A1POLBSMN1; SMN2EPHX2 | |
| SCHEMBL20741141 | 0.75 | PAK4 (0.39) | ALDH1A1POLBSMN1; SMN2BTKHTT | |
| SCHEMBL17872122 | 0.75 | PAK4 (0.39) | ALDH1A1POLBSMN1; SMN2BTKHTT | |
| SCHEMBL17872159 | 0.74 | SMN1; SMN2 (0.43) | ALDH1A1POLBSMN1; SMN2EPHX2LMNA | |
| SCHEMBL17872959 | 0.72 | SMN1; SMN2 (0.41) | ALDH1A1POLBSMN1; SMN2EPHX2LMNA | |
| SCHEMBL22164627 | 0.72 | LMNA (0.41) | ALDH1A1SMN1; SMN2EPHX2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220024929-A9 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-01-27 | — | — | US | disclosed |
| US-20210115051-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-22 | — | — | US | disclosed |
| US-10870651-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190055248-A1 | INHIBITORS OF CYCLINDEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. | 2019-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220024929-A9 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | ALDH1A1 4404/4885POLB 694/4885SMN1; SMN2 1868/4885 |
| US-20190055248-A1 | INHIBITORS OF CYCLINDEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | ALDH1A1 4277/4885POLB 803/4885SMN1; SMN2 1988/4885 |
| US-20210115051-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | ALDH1A1 4404/4885POLB 694/4885SMN1; SMN2 1868/4885 |
| US-10870651-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | CDK7, CDK3, CDK9 | ALDH1A1 4404/4885POLB 694/4885SMN1; SMN2 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.