Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9579281 | 0.80 | EEF2K (0.60) | EEF2KKDM4ECYP19A1ALDH1A1ALDH2 | |
| SCHEMBL29657292 | 0.74 | KDM4E (0.56) | EEF2KKDM4ECYP19A1ALDH1A1ALDH2 | |
| SCHEMBL8873657 | 0.74 | KDM4E (0.56) | EEF2KKDM4ECYP19A1ALDH1A1ALDH2 | |
| SCHEMBL181713 | 0.74 | KDM4E (0.56) | EEF2KKDM4ECYP19A1ALDH1A1ALDH2 | |
| SCHEMBL29854631 | 0.74 | HTR2C (0.39) | KDM4ENOS3NOS2ALDH1A1TSHR | |
| SCHEMBL14939858 | 0.73 | NOS3 (0.50) | EEF2KCYP19A1NOS3NOS2KIF11 | |
| SCHEMBL10983553 | 0.73 | KDM4E (0.55) | EEF2KKDM4ECYP19A1ALDH1A1ALDH2 | |
| SCHEMBL28829408 | 0.73 | ALDH1A1 (0.44) | EEF2KALDH1A1KIF11HDAC4GAA | |
| SCHEMBL6591640 | 0.71 | MAOB (0.53) | EEF2KKDM4ECYP19A1HTR2CHTR2B | |
| SCHEMBL9329821 | 0.71 | KDM4E (0.59) | EEF2KKDM4EALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |