Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067765 | 0.83 | TP53 (0.57) | P2RX7THRBALDH1A1MAPTLMNA | |
| SCHEMBL7695920 | 0.81 | ALDH1A1 (0.51) | P2RX7CYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL28276335 | 0.81 | ALDH1A1 (0.51) | THRBCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8276876 | 0.80 | ALDH1A1 (0.49) | P2RX7THRBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1243390 | 0.80 | ALDH1A1 (0.51) | P2RX7THRBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6318911 | 0.79 | CYP2C19 (0.74) | CYP3A4CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL16463886 | 0.79 | P2RX7 (0.67) | P2RX7THRBCYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL20600115 | 0.79 | LMNA (0.51) | P2RX7THRBCYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL21838887 | 0.79 | LMNA (0.51) | P2RX7THRBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11651599 | 0.78 | OPRL1 (0.58) | CYP3A4CYP2C19ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019036024-A1 | 2-(1,1 '-BIPHENYL)-1 H-BENZO[D]IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS APELIN AND APJ AGONISTS FOR TREATING CARDIOVASCULAR DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-21 | — | — | WO | disclosed |