Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20746152 | 0.83 | P2RX7 (0.60) | TP53LMNAALDH1A1MAPTP2RX7 | |
| SCHEMBL2343711 | 0.75 | NPC1 (0.56) | LMNAALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL23728129 | 0.73 | NPC1 (0.75) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL8842386 | 0.72 | MAPT (0.59) | LMNAHTTALDH1A1MAPTKMT2A | |
| SCHEMBL2085614 | 0.72 | MAPT (0.62) | LMNAHTTALDH1A1MAPTPKM | |
| SCHEMBL23727617 | 0.72 | NPC1 (0.52) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL7226059 | 0.71 | MAPT (0.54) | LMNAHTTALDH1A1MAPTKMT2A | |
| SCHEMBL5523347 | 0.71 | MAPT (0.51) | TP53LMNAHTTALDH1A1MAPT | |
| SCHEMBL6073665 | 0.70 | MAPT (0.52) | LMNAHTTALDH1A1MAPTPKM | |
| SCHEMBL24994429 | 0.69 | ALDH1A1 (0.62) | LMNAHTTALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132500-A1 | Antibiotic compounds | MERCK SHARP & DOHME CORP. | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132500-A1 | Antibiotic compounds | NRDC, MRPL21, PEPD | TP53 935/4885LMNA 3549/4885HTT 3457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.