Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745576 | 0.90 | LMNA (0.41) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20745728 | 0.76 | LMNA (0.41) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20745518 | 0.71 | ALDH1A1 (0.47) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20745512 | 0.69 | LMNA (0.54) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25019676 | 0.68 | MAPK1 (0.34) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20745593 | 0.68 | LMNA (0.45) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20746532 | 0.67 | SMN1; SMN2 (0.45) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31338415 | 0.66 | LMNA (0.50) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20745714 | 0.65 | LMNA (0.42) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20745645 | 0.64 | ALDH1A1 (0.44) | KDM4ELMNAMAPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668881-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS | Agios Pharmaceuticals, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019035863-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS | AGIOS PHARMACEUTICALS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |