Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.31 |
| ▸ | TPMT | P51580 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20748511 | 0.86 | NOTUM (0.39) | NOTUMTDP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL20748517 | 0.84 | — | — | |
| SCHEMBL20748619 | 0.81 | EGLN1 (0.35) | TDP1SMYD3BRD4 | |
| SCHEMBL20748646 | 0.76 | ALDH1A1 (0.36) | GAA | |
| SCHEMBL20748604 | 0.72 | BRD4 (0.41) | NPC1GAASMYD3BRD4BAZ2B | |
| SCHEMBL20748490 | 0.71 | ALDH1A1 (0.33) | BAZ2BBAZ2A | |
| SCHEMBL70598 | 0.68 | SMN1; SMN2 (0.62) | NOTUMTDP1SMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL28339344 | 0.66 | SMN1; SMN2 (0.60) | NOTUMTDP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8284047 | 0.63 | TDP1 (0.58) | NOTUMTDP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL29159168 | 0.63 | SMN1; SMN2 (0.56) | NOTUMTDP1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473501-B1 | COMPOUNDS AS TYROSINE KINASE MODULATORS | ALLERGAN INC (US) | 2019-02-20 | — | — | EP | disclosed |