Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16700392 | 0.78 | NISCH (0.35) | CSNK1DCSNK1EFYNKMONISCH | |
| SCHEMBL16699604 | 0.76 | PIK3C3 (0.44) | CSNK1DCSNK1EFYNKMONISCH | |
| SCHEMBL16722624 | 0.70 | KMO (0.42) | CSNK1DCSNK1EFYNKMONISCH | |
| SCHEMBL16700318 | 0.70 | CSNK1E (0.46) | CSNK1DCSNK1EFYNKMOCASP1 | |
| SCHEMBL16700658 | 0.63 | MAPKAPK2 (0.42) | KMONISCHCASP1ERCC1ERCC4 | |
| SCHEMBL16699092 | 0.62 | CSNK1E (0.55) | CSNK1DCSNK1EKMO | |
| SCHEMBL21759157 | 0.59 | TGFBR1 (0.45) | FYNKMONISCHCASP1TGFBR1 | |
| SCHEMBL5385913 | 0.59 | GABRP (0.40) | KMONISCHCASP1MAPT | |
| SCHEMBL14844945 | 0.59 | NISCH (0.38) | KMONISCH | |
| SCHEMBL3395650 | 0.58 | KMO (0.49) | FYNKMOCASP1ERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068784-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-20 | — | — | EP | disclosed |