Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 9/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752081 | 0.91 | PRKCQ (0.59) | PRKCQLRRK2BRD4IGF1R | |
| SCHEMBL20752134 | 0.90 | PRKCQ (0.58) | PRKCQLRRK2BRD4JAK2 | |
| SCHEMBL20752186 | 0.88 | PRKCQ (0.56) | PRKCQLRRK2BRD4JAK2JAK1 | |
| SCHEMBL20752181 | 0.87 | LRRK2 (0.62) | PRKCQLRRK2 | |
| SCHEMBL20752144 | 0.87 | PRKCQ (0.55) | PRKCQLRRK2 | |
| SCHEMBL20752079 | 0.82 | PRKCQ (0.51) | PRKCQIGF1R | |
| SCHEMBL3495246 | 0.82 | PRKCQ (0.85) | PRKCQLRRK2BRD4JAK2JAK1 | |
| SCHEMBL20752307 | 0.82 | JAK2 (0.55) | BRD4JAK2JAK1JAK3IGF1R | |
| SCHEMBL20752218 | 0.80 | LRRK2 (0.56) | PRKCQLRRK2BRD4JAK2JAK1 | |
| SCHEMBL1871031 | 0.79 | PRKCQ (0.53) | PRKCQLRRK2BRD4JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |