Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 9/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752168 | 0.88 | PRKCQ (0.59) | PRKCQLRRK2IGF1RBRD4EIF2AK4 | |
| SCHEMBL20752081 | 0.87 | PRKCQ (0.59) | PRKCQLRRK2IGF1RBRD4SYK | |
| SCHEMBL20752134 | 0.86 | PRKCQ (0.58) | PRKCQLRRK2BRD4JAK2 | |
| SCHEMBL20752181 | 0.84 | LRRK2 (0.62) | PRKCQLRRK2 | |
| SCHEMBL20752144 | 0.84 | PRKCQ (0.55) | PRKCQLRRK2 | |
| SCHEMBL20752222 | 0.82 | IGF1R (0.51) | LRRK2IGF1RBRD4SYKJAK2 | |
| SCHEMBL20752318 | 0.82 | LRRK2 (0.51) | PRKCQLRRK2BRD4 | |
| SCHEMBL15769403 | 0.80 | PRKCQ (0.61) | PRKCQBRD4SYK | |
| SCHEMBL20752196 | 0.80 | LRRK2 (0.49) | PRKCQLRRK2SYK | |
| SCHEMBL20752079 | 0.79 | PRKCQ (0.51) | PRKCQIGF1RSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |