Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 8/20 | 0.57 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752168 | 0.87 | PRKCQ (0.59) | LRRK2PRKCQ | |
| SCHEMBL20752081 | 0.86 | PRKCQ (0.59) | LRRK2PRKCQ | |
| SCHEMBL20752134 | 0.85 | PRKCQ (0.58) | LRRK2PRKCQ | |
| SCHEMBL20752186 | 0.84 | PRKCQ (0.56) | LRRK2PRKCQ | |
| SCHEMBL3495110 | 0.83 | PRKCQ (0.81) | LRRK2PRKCQULK1MAPK3 | |
| SCHEMBL20752144 | 0.83 | PRKCQ (0.55) | LRRK2PRKCQ | |
| SCHEMBL20752169 | 0.82 | ULK1 (0.63) | LRRK2ULK1MAPK3 | |
| SCHEMBL20752302 | 0.82 | LRRK2 (0.71) | LRRK2ULK1 | |
| SCHEMBL20752159 | 0.81 | LRRK2 (0.68) | LRRK2ULK1 | |
| SCHEMBL15769404 | 0.80 | PRKCQ (0.62) | LRRK2PRKCQULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |